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Index > Protein center > Olr1(Gene name) > Mouse
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  • Olr1 (Gene name),
  • Oxidized low-density lipoprotein receptor 1 (Protein name ),  OLR1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Olr1(Lox1);
    Protein name:
    Oxidized low-density lipoprotein receptor 1(Ox-LDL receptor 1);
    Alternative:
    Lectin-type oxidized LDL receptor 1;Lectin-like oxidized LDL receptor 1(LOX-1;Lectin-like oxLDL receptor 1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.
    Function:
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein Secreted A secreted form also exists.
    Protein Attributes:
    Sequence length:
    363
    Sequence:
    50:
    MTFDDKMKPA | NDEPDQKSCG | KKPKGLHLLS | SPWWFPAAMT | LVILCLVLSV | 
    100:
    TLIVQWTQLR | QVSDLLKQYQ | ANLTQQDRIL | EGQMLAQQKA | ENTSQESKKE | 
    150:
    LKGKIDTLTQ | KLNEKSKEQE | ELLQKNQNLQ | EALQRAANSS | EESQRELKGK | 
    200:
    IDTITRKLDE | KSKEQEELLQ | MIQNLQEALQ | RAANSSEESQ | RELKGKIDTL | 
    250:
    TLKLNEKSKE | QEELLQKNQN | LQEALQRAAN | FSGPCPQDWL | WHKENCYLFH | 
    300:
    GPFSWEKNRQ | TCQSLGGQLL | QINGADDLTF | ILQAISHTTS | PFWIGLHRKK | 
    350:
    PGQPWLWENG | TPLNFQFFKT | RGVSLQLYSS | GNCAYLQDGA | VFAENCILIA | 
    363:
    FSICQKKTNH | LQI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ox-LDL receptor 1
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    E1859h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    E1859r
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    96T
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    ELISA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    E1859m
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    ELISA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    E1859b
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    96T
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    ELISA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    E1859p
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    Packing:
    96T
    ELISA Kit for Mouse Ox-LDL receptor 1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    U1859r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    U1859m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ox-LDL receptor 1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    U1859b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    U1859h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ox-LDL receptor 1
    Cat.:
    U1859p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Cat.:
    P1859Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Cat.:
    P1859Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Cat.:
    P1859Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Monoclonal Antibody for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1
    Protein for Mouse Ox-LDL receptor 1

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    References
    1. 1.
      "High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1)."
      Hoshikawa H. , Sawamura T. , Kakutani M. , Aoyama T. , Nakamura T. , Masaki T.
      Biochem. Biophys. Res. Commun.245:841-846(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Mouse LOX-1 is expressed in mast cells after IgE cross-linking."
      Park S.-H. , Ahn H.-J. , Cho J.-J.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
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